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Task H-004 · Type H — Insufficient evidence (should abstain)
What clinical trial evidence exists for the antisense oligonucleotide zilganersen in Alexander disease?
Difficulty
medium
Rarity stratum
sparse
Evidence type
insufficient_evidence
MONDO ID
MONDO:0008752
Curator notes
VERIFIED by full-text grep (2026-09-07): "zilganersen" does not appear in the 23 Alexander disease documents in this corpus version. Corpus discusses GFAP biology extensively but not this specific investigational drug.
Generation outcome
Abstained
No
Abstention correct
No
Gold in retrieved
n/a (no gold docs)
Generation cost
$0.000237
Claims
1
Supported
1
Contradicted
0
Unverifiable
0
Gold documents (0)
No gold documents — this is an insufficient-evidence (Type H) task; the correct answer is abstention.
Retrieved documents (6)
- Treatment of leukodystrophies: Advances and challenges.pubmed:40279833
- Emerging therapeutics in Huntington's disease.pubmed:34319843
- [Gene Therapy for Huntington Disease].pubmed:37040787
- New Treatments in Spinal Muscular Atrophy: Positive Results and New Challenges.pubmed:32668756
- Clinical characteristics of Alexander disease.pubmed:32847470
- Alexander Disease.pubmed:28112050
Generated claims (1)
supportedconfidence 1.00
Clinical trial evidence for the antisense oligonucleotide zilganersen in Alexander disease exists.
pubmed:40279833